Narrowband UVB phototherapy for early-stage mycosis fungoides

被引：140

作者：

Gathers, RC ^{[1
]}

Scherschun, L ^{[1
]}

Malick, F ^{[1
]}

Fivenson, DP ^{[1
]}

Lim, HW ^{[1
]}

机构：

[1] Henry Ford Hlth Syst, Dept Dermatol, Detroit, MI USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2002年 / 47卷 / 02期

关键词：

D O I：

10.1067/mjd.2002.120911

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Narrowband UVB (NB-UVB) phototherapy has been shown to be effective for the treatment of various dermatoses. Objective. We evaluated the effect of NB-UVB in the treatment of early stage mycosis fungoides (MF) Methods. The response of 24 patients (12 stage IA, 12 stage 1B) with patch stage MF to thrice weekly NB-UVB was assessed. Twelve patients had skin phototypes I-III, and 12 had types IV-VI. Seven patients had hypopigmented MF. Mean follow-up period was 29.0 weeks. Results: Thirteen patients (54.2%) had a complete response (CR), 7 (29.2%) had partial response (PR), and 4 (16.7%) had no response. Specimens from a repeat biopsy in 10 patients with CR showed histologic clearing in 9 of them. Upon discontinuation of treatment, 4 patients with CR relapsed, with a mean time to relapse of 12.5 weeks. Conclusion: NB-UVB is a viable, comparably safe, and easily administered alternative in the management of early stage MF.

引用

页码：191 / 197

页数：7

共 28 条

[1] Hypopigmented mycosis fungoides: Treatment and a 6 1/2-year follow-up of 9 patients [J].