Osteonectin-expressing cells in human stomach cancer and their possible clinical significance

被引：25

作者：

Maeng, HY

Song, SB

Choi, DK

Kim, KE

Jeong, HY

Sakaki, Y

Furihata, C

机构：

[1] Univ Tokyo, Lab Funct Genom, Ctr Human Genome, Inst Med Sci,Minato Ku, Tokyo 1088639, Japan

[2] Univ Joong Bu, Dept Life Sci, Chungnam 312702, South Korea

[3] Chungnam Natl Univ, Dept Biochem, Inst Biotechnol, Taejon 305764, South Korea

[4] Chungnam Natl Univ Hosp, Dept Internal Med, Taejon 301721, South Korea

[5] Aoyama Gakuin Univ, Coll Sci & Engn, Atsugi, Kanagawa 2430123, Japan

来源：

CANCER LETTERS | 2002年 / 184卷 / 01期

关键词：

osteonectin; human stomach adenocarcinoma; osteonectin-mAb staining; competitive reverse transcriptase polymerase chain; reaction;

D O I：

10.1016/S0304-3835(02)00191-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The clinical significance of osteonectin in human stomach cancer was examined immunohistochemically and molecular biologically in 31 differentiated and eight undifferentiated stomach adenocarcinomas and 19 non-cancer stomach tissues. Osteonectin-mAb-stained cells were observed in stroma of 90% differentiated and 63% undifferentiated adenocarcinomas, and of 26% non-cancer stomach tissues. Competitive reverse transcriptase polymerase chain reaction results generally coincided with immunohistochemical data. The present results suggest that osteonectin is highly expressed in reactive stroma associated with invasive differentiated adenocarcinomas and that it may serve as a useful clinical diagnostic marker for stomach cancer. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：117 / 121

页数：5

共 15 条

[11] Molecular epidemiology, pathogenesis and prevention of gastric cancer [J].