Polymorphism of TAP1 and TAP2 in Japanese patients with rheumatoid arthritis

被引：13

作者：

Takeuchi, F ^{[1
]}

Nakano, K ^{[1
]}

Matsuta, K ^{[1
]}

Takizawa, K ^{[1
]}

Nabeta, H ^{[1
]}

Kuwata, S ^{[1
]}

Ito, K ^{[1
]}

机构：

[1] UNIV TOKYO, FAC MED, DEPT TRANSFUS MED & IMMUNOL, BUNKYO KU, TOKYO 113, JAPAN

来源：

TISSUE ANTIGENS | 1997年 / 49卷 / 03期

关键词：

DR; Japanese; RA; TAP;

D O I：

10.1111/j.1399-0039.1997.tb02753.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Contribution of polymorphism of transporter associated with antigen processing 1 and 2 (TAP1 and 2) alleles to pathogenesis of Japanese rheumatoid arthritis (RA) was studied in 92 RA patients by PCR-RFLP. The allele frequency of TAP2A was slightly low (38.0%) and the frequencies of TAP2B and TAP2C were slightly high (39.7% and 17.9%) in RA, but these differences were not significant. These increases and decrease were due to the positive or negative associations with HLA-DRB1*0405. It was very likely that slight differences in TAP2A, TAP2B and TA2C in RA were secondary phenomenon reflecting an increase in HLA-DRB1*0405. The prevalence of TAP2E allele was low (3.3%, P<0.01, P-c=not significant) and not correlated with HLA-DRB1*0405.

引用

页码：280 / 282

页数：3

共 10 条

[1] GONZALEZESCRIBANO F, 1995, TISSUE ANTIGENS, V45, P77
[2] Lack of primary association between transporter associated with antigen processing genes and atopic dermatitis
Kuwata, S
Yanagisawa, M
Saeki, H
Nakagawa, H
Etoh, T
Tokunaga, K
Juji, T
Shibata, Y
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1995, 96 (06) : 1051 - 1060
[3] PROCESSING PATHWAYS FOR PRESENTATION OF CYTOSOLIC ANTIGEN TO MHC CLASS-II-RESTRICTED T-CELLS
MALNATI, MS
MARTI, M
LAVAUTE, T
JARAQUEMADA, D
BIDDISON, W
DEMARS, R
LONG, EO
[J]. NATURE, 1992, 357 (6380) : 702 - 704
[4] ASSOCIATION OF TAP2 POLYMORPHISM WITH RHEUMATOID-ARTHRITIS IS SECONDARY TO ALLELIC ASSOCIATION WITH HLA-DRB1
MARSAL, S
HALL, MA
PANAYI, GS
LANCHBURY, JS
[J]. ARTHRITIS AND RHEUMATISM, 1994, 37 (04): : 504 - 513
[5] ALLELES AND HAPLOTYPES OF THE MHC-ENCODED ABC TRANSPORTERS TAP1 AND TAP2
POWIS, SH
TONKS, S
MOCKRIDGE, I
KELLY, AP
BODMER, JG
TROWSDALE, J
[J]. IMMUNOGENETICS, 1993, 37 (05) : 373 - 380
[6] EFFECT OF POLYMORPHISM OF AN MHC-LINKED TRANSPORTER ON THE PEPTIDES ASSEMBLED IN A CLASS-I MOLECULE
POWIS, SJ
DEVERSON, EV
COADWELL, WJ
CIRUELA, A
HUSKISSON, NS
SMITH, H
BUTCHER, GW
HOWARD, JC
[J]. NATURE, 1992, 357 (6375) : 211 - 215
[7] SINGAL DP, 1994, CLIN EXP RHEUMATOL, V12, P29
[8] TAKEDA F, 1990, ADV PAIN RES THER, V16, P475
[9] TAKEUCHI F, 1994, J RHEUMATOL, V21, P857
[10] ANALYSIS OF THE MHC-ENCODED TRANSPORTERS TAP1 AND TAP2 IN RHEUMATOID-ARTHRITIS - LINKAGE WITH DR4 ACCOUNTS FOR THE ASSOCIATION WITH A MINOR TAP2 ALLELE
WORDSWORTH, BP
PILE, KD
GIBSON, K
BURNEY, RO
MOCKRIDGE, I
POWIS, SH
[J]. TISSUE ANTIGENS, 1993, 42 (03): : 153 - 155

← 1 →