Synthesis of the apoptosis inducing agent apoptolidin. Assembly of the C(16)-C(28) fragment

被引：47

作者：

Sulikowski, GA ^{[1
]}

Lee, WM ^{[1
]}

Jin, B ^{[1
]}

Wu, B ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 10期

关键词：

D O I：

10.1021/ol005769v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A stereoselective synthesis of the C(16)-C(28) fragment of the apoptosis inducing agent apoptolidin is described. Key steps include two propionate aldol reactions and a stereoselective Mukaiyama aldol addition of enolsilane 19 to beta-methoxy aldehyde 4.

引用

页码：1439 / 1442

页数：4

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