Aqueous N-alkylation of amines using alkyl halides:: direct generation of tertiary amines under microwave irradiation

被引：81

作者：

Ju, YH ^{[1
]}

Varma, RS ^{[1
]}

机构：

[1] US EPA, Clean Proc Branch, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA

来源：

GREEN CHEMISTRY | 2004年 / 6卷 / 04期

关键词：

D O I：

10.1039/b401620c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Direct formation of tertiary amines via N-alkylation of amines by alkyl halides occurs in aqueous media under microwave irradiation. This greener alternative is also a useful and powerful method to construct C - N bond without using any transition metal catalysts.

引用

页码：219 / 221

页数：3

共 24 条

[1] Remarkable fast n-alkylation of azaheterocycles under microwave irradiation in dry media [J].

Bogdal, D ;

Pielichowski, J ;

Jaskot, K .

HETEROCYCLES, 1997, 45 (04) :715-722

[2] Preparation of diethylisopropylamine [J].

Caspe, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1932, 54 :4457-4457

[3] Solvent-free phase transfer catalysis under microwaves in fullerene chemistry. A convenient preparation of N-alkylpyrrolidino[60]fullerenes. [J].

de la Cruz, P ;

de la Hoz, A ;

Font, LM ;

Langa, F ;

Perez-Rodriguez, MC .

TETRAHEDRON LETTERS, 1998, 39 (33) :6053-6056

[4] Dielectric parameters relevant to microwave dielectric heating [J].

Gabriel, C ;

Gabriel, S ;

Grant, EH ;

Halstead, BSJ ;

Mingos, DMP .

CHEMICAL SOCIETY REVIEWS, 1998, 27 (03) :213-223

[5] Concerning phenylization in the presence of copper as a catalytic agent. [J].

Goldberg, I .

BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1906, 39 :1691-1692

[6]

HARTWIG JF, 1998, ANGEW CHEM INT EDIT, V37, P2406

[7]

Hayes, 2002, MICROWAVE SYNTHESIS, P29

[8] The preparation of secondary alkylarylamines and their purification [J].

Hickinbottom, WJ .

JOURNAL OF THE CHEMICAL SOCIETY, 1930, :992-994

[9] NEMATOCIDAL ACTIVITY OF LONG ALKYL CHAIN AMIDES, AMINES, AND THEIR DERIVATIVES ON DOG ROUNDWORM LARVAE [J].

KIUCHI, F ;

NISHIZAWA, S ;

KAWANISHI, H ;

KINOSHITA, S ;

OHSIMA, H ;

UCHITANI, A ;

SEKINO, N ;

ISHIDA, M ;

KONDO, K ;

TSUDA, Y .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (12) :3234-3244

[10] Microwave-accelerated homogeneous catalysis in organic chemistry [J].

Larhed, M ;

Moberg, C ;

Hallberg, A .

ACCOUNTS OF CHEMICAL RESEARCH, 2002, 35 (09) :717-727

← 1 2 3 →