Evaluation of available IgE-binding epitope data and its utility in bioinformatics

被引:40
作者
Bannon, Gary A.
Ogawa, Tadashi
机构
[1] Monsanto Co, St Louis, MO 63167 USA
[2] Kansai Univ Welf Sci, Osaka, Japan
关键词
allergen; crossreactivity; conformational epitope; genetic engineering; linear epitope;
D O I
10.1002/mnfr.200500276
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
This paper reviews the role played by IgE-binding epitopes in eliciting clinical symptoms, the types of IgE-binding epitopes in allergenic proteins, the methods used to identify IgE-binding epitopes, and the availability of IgE-binding epitopes in allergenic sources. Finally, bioinformatics methods to assess protein allergenicity using knowledge of IgE-binding epitopes are discussed.
引用
收藏
页码:638 / 644
页数:7
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