NF1 tumor suppressor protein and mRNA in skeletal tissues of developing and adult normal mouse and NF1-deficient embryos

被引：64

作者：

Kuorilehto, T

Nissinen, M

Koivunen, J

Benson, MD

Peltonen, J

机构：

[1] Univ Oulu, Dept Anat & Cell Biol, FIN-90014 Oulu, Finland

[2] Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX USA

[3] Univ Oulu, Dept Dermatol, Oulu, Finland

[4] Univ Turku, Dept Med Biochem, Turku, Finland

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 06期

关键词：

neurofibromatosis; neurofibromin; cartilage; bone; Ras;

D O I：

10.1359/JBMR.040130

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

NF1 is a heritable disease with multiple osseous lesions. The expression of the NF1 gene was studied in embryonic and adult rodent skeleton and in NF1-deficient embryos. The NF1 gene was expressed intensely in the cartilage and the periosteum. Impaired NF1 expression may lead to inappropriate development and dynamics of bones and ultimately to the osseous manifestations of the disease.

引用

收藏

页码：983 / 989

页数：7

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