Solid phase synthesis of chiral 3-substituted quinazoline-2,4-diones

被引：88

作者：

Gouilleux, L

Fehrentz, JA

Winternitz, F

Martinez, J

机构：

[1] UNIV MONTPELLIER 1,CNRS,LAB AMINOACIDES PEPTIDES & PROT,LAPP,ESA 5075,FAC PHARM,F-34060 MONTPELLIER,FRANCE

[2] UNIV MONTPELLIER 2,CNRS,LAB AMINOACIDES PEPTIDES & PROT,LAPP,ESA 5075,FAC PHARM,F-34060 MONTPELLIER,FRANCE

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 39期

关键词：

D O I：

10.1016/0040-4039(96)01541-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of chiral 3-substituted quinazoline-2,4-diones was performed starting from N-urethane anthranilamides. This synthetic pathway was applied in solid phase, from commercially available anthranilic acid that was bound to hydroxymethyl polystyrene resin via a carbamate linker. In both cases, cyclisation occurred under basic conditions to afford non-racemized quinazolinediones in high purity. Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：7031 / 7034

页数：4

共 15 条

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