Solid phase synthesis of chiral 3-substituted quinazoline-2,4-diones

被引:88
作者
Gouilleux, L
Fehrentz, JA
Winternitz, F
Martinez, J
机构
[1] UNIV MONTPELLIER 1,CNRS,LAB AMINOACIDES PEPTIDES & PROT,LAPP,ESA 5075,FAC PHARM,F-34060 MONTPELLIER,FRANCE
[2] UNIV MONTPELLIER 2,CNRS,LAB AMINOACIDES PEPTIDES & PROT,LAPP,ESA 5075,FAC PHARM,F-34060 MONTPELLIER,FRANCE
关键词
D O I
10.1016/0040-4039(96)01541-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of chiral 3-substituted quinazoline-2,4-diones was performed starting from N-urethane anthranilamides. This synthetic pathway was applied in solid phase, from commercially available anthranilic acid that was bound to hydroxymethyl polystyrene resin via a carbamate linker. In both cases, cyclisation occurred under basic conditions to afford non-racemized quinazolinediones in high purity. Copyright (C) 1996 Published by Elsevier Science Ltd
引用
收藏
页码:7031 / 7034
页数:4
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