SYNTHESIS OF CHIRAL 3-SUBSTITUTED 2,4(1H,3H)-QUINAZOLINEDIONES

被引：34

作者：

CANONNE, P ^{[1
]}

AKSSIRA, M ^{[1
]}

DAHDOUH, A ^{[1
]}

KASMI, H ^{[1
]}

BOUMZEBRA, M ^{[1
]}

机构：

[1] UNIV ABDELMALEK ESSAADI,FAC SCI,DEPT CHIM,TETOUAN,MOROCCO

来源：

HETEROCYCLES | 1993年 / 36卷 / 06期

关键词：

D O I：

10.3987/COM-92-6296

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Carbomethoxyphenyl isocyanate and 6-nitro-2-carbomethoxyphenyl isocyanate were generated in situ from half-esters, and then converted into the corresponding quinazolinediones using alpha-amino acids. This useful annelation process was found to be a general method for the formation of various chiral 3-substituted quinazolinediones.

引用

页码：1305 / 1314

页数：10

共 19 条

[1] SYNTHESIS OF SOME SUBSTITUTED QUINAZOLINEDIONES AS POTENTIAL INHIBITORS OF SMOOTH-MUSCLE CONTRACTION
AKGUN, H
HOLLSTEIN, U
HURWITZ, L
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1988, 77 (09) : 735 - 739
[2] NEW APPLICATION OF AMINO-ACID N-CARBOXY ANHYDRIDES - SYNTHESIS OF 1,4-BENZODIAZEPINE-2,5-DIONES
AKSSIRA, M
KASMI, H
DAHDOUH, A
BOUMZEBRA, M
[J]. TETRAHEDRON LETTERS, 1992, 33 (14) : 1887 - 1888
[3] BURCKHALER JH, 1956, J AM PHARM ASSOC, V44, P545
[4] CHAN N, 1982, J HETEROCYCLIC CHEM, V19, P541
[5] DAS B, 1963, J INDIAN CHEM SOC, V40, P35
[6] ELLIS GP, 1987, SYNTHESIS FUSED HETE, V47
[7] NEW SEDATIVE AND HYPOTENSIVE 3-SUBSTITUTED 2,4(1H,3H)-QUINAZOLINEDIONES
HAYAO, S
HAVERA, HJ
STRYCKER, WG
LEIPZIG, TJ
KULP, RA
HARTZLER, HE
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (06) : 807 - &
[8] Kaiser C., 1988, ORG SYNTH, V6, P910
[9] SYNTHESIS AND ANTI-CONVULSANT TESTING OF 4-PHENYLSEMICARBAZIDES
KORNET, MJ
CHU, JY
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1983, 72 (10) : 1213 - 1215
[10] SYNTHESIS OF 3-AMINO-2,4(1H,3H)-QUINAZOLINEDIONES FOR TESTING AS ANTICONVULSANTS
KORNET, MJ
VARIA, T
BEAVEN, W
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1984, 21 (05) : 1533 - 1535

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