mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats

被引：39

作者：

Besheer, Joyce ^{[1
]}

Stevenson, Rebekah A. ^{[1
]}

Hodge, Clyde W. ^{[1
]}

机构：

[1] Univ N Carolina, Bowles Ctr Alcohol Studies, Dept Psychiat, Chapel Hill, NC 27599 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2006年 / 551卷 / 1-3期

关键词：

alcohol; drug discrimination; discriminative stimulus; ethanol intake; metabotropic glutamate receptors; self-administration;

D O I：

10.1016/j.ejphar.2006.08.071

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Recent work has identified a role for metabotropic glutamate receptor subtype 5 (mGlu(5)) in the discriminative stimulus properties of investigator-administered ethanol. The purpose of this study was to determine if mGlu(5) receptors modulate the discriminative stimulus properties of self-administered ethanol. Results show that the mGlu(5) receptor antagonist 6-Methyl-2-(phenylethynyl)pyridine (MPEP; 10 mg/kg) inhibited the discriminative stimulus properties of consumed ethanol during a self-administration test session. Further, 10 mg/kg MPEP increased and 1 mg/kg MPEP decreased the amount of self-administered ethanol required to produce full substitution. These results indicate that mGlu(5) receptors are involved in the expression of the discriminative stimulus properties of self-administered ethanol. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：71 / 75

页数：5

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