The Microenvironmental Landscape of Brain Tumors

被引：1497

作者：

Quail, Daniela F. ^{[1
,2
]}

Joyce, Johanna A. ^{[3
,4
]}

机构：

[1] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada

[2] McGill Univ, Dept Physiol, Montreal, PQ H3A 1A3, Canada

[3] Univ Lausanne, Ludwig Inst Canc Res, CH-1066 Lausanne, Switzerland

[4] Univ Lausanne, Dept Oncol, Chemin Boveresses 155, CH-1066 Lausanne, Switzerland

来源：

CANCER CELL | 2017年 / 31卷 / 03期

关键词：

CANCER STEM-CELLS; HUMAN BREAST-CANCER; PERIVASCULAR NICHE; VASCULAR NORMALIZATION; MOLECULAR-MECHANISMS; LYMPHOCYTE RATIO; MICROGLIAL CELLS; LUNG-CANCER; T-CELLS; ANTIANGIOGENIC THERAPY;

D O I：

10.1016/j.ccell.2017.02.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here, we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TME in cancer. By developing a comprehensive understanding of the complex and interconnected microenvironmental landscape of brain malignancies we will greatly expand the range of therapeutic strategies available to target these deadly diseases.

引用

页码：326 / 341

页数：16

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