Transmission of chronic nociception by spinal neurons expressing the substance P receptor

被引：345

作者：

Nichols, ML

Allen, BJ

Rogers, SD

Ghilardi, JR

Honore, P

Luger, NM

Finke, MP

Li, J

Lappi, DA

Simone, DA

Mantyh, PW ^{[1
]}

机构：

[1] Univ Minnesota, Dept Prevent Sci, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA

[5] Vet Affairs Med Ctr, Mol Neurobiol Lab 151, Minneapolis, MN 55417 USA

[6] Adv Targeting Syst, San Diego, CA 92121 USA

来源：

SCIENCE | 1999年 / 286卷 / 5444期

关键词：

D O I：

10.1126/science.286.5444.1558

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Substance P receptor (SPR)-expressing spinal neurons were ablated with the selective cytotoxin substance P-saporin. Loss of these neurons resulted in a reduction of thermal hyperalgesia and mechanical allodynia associated with persistent neuropathic and inflammatory pain states. This Loss appeared to be permanent. Responses to mildly painful stimuli and morphine analgesia were unaffected by this treatment. These results identify a target for treating persistent pain and suggest that the small population of SPR-expressing neurons in the dorsal horn of the spinal cord plays a pivotal role in the generation and maintenance of chronic neuropathic and inflammatory pain.

引用

页码：1558 / 1561

页数：4

共 25 条

[1] LACK OF ANALGESIC EFFECT OF OPIOIDS ON NEUROPATHIC AND IDIOPATHIC FORMS OF PAIN [J].