Advances in the early detection of Alzheimer's disease

被引：362

作者：

Nestor, PJ

Scheltens, P

Hodges, JR

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

[2] VU Med Centrum, Alzheimer Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands

[3] MRC, Cognit & Brain Sci Unit, Cambridge CB2 2EF, England

来源：

NATURE MEDICINE | 2004年 / 10卷 / 07期

关键词：

D O I：

10.1038/nrn1433

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The combination of an aging population and the promise, possibly in the near future, of disease-modifying therapies have made the characterization of the early stages of Alzheimer's disease (AD) a topic of major research interest. In this article we review recent progress in our understanding of the evolution of early AD with particular reference to the symptomatic pre-dementia stage designated 'mild cognitive impairment', emphasizing work on the early cognitive profile and associated neuroimaging studies.

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页码：S34 / S41

页数：8

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