The chemical-biological interface: Developments in automated and miniaturised screening technology

被引：63

作者：

Houston, JG

Banks, M

机构：

[1] Lead Discovery Unit, Glaxo Wellcome Medicines Res. Centre, Stevenage, Hertfordshire, SG1 2NY, Gunnels Wood Road

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1997年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(97)80128-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The rapidly changing developments in genomics and combinatorial chemistry, generating new drug targets and large numbers of compounds, have caused a revolution in high-throughput screening technologies. Key to this revolution has been the introduction of robotics and automation, together with new biological assay technologies (e.g., homogeneous time resolved fluorescence), With ever increasing workloads, together with economic and logistical constraints, miniaturisation is rapidly becoming essential for the future of high-throughput screening and combinatorial chemistry. This is evident from the introduction of high-density microtitre plates, small volume liquid handling robots and associated detection technology. (C) Current Biology Ltd ISSN 0958-1669.

引用

页码：734 / 740

页数：7

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