Biocompatible, hydrophilic, supramolecular carbon nanoparticles for cell delivery

被引：76

作者：

Yan, Aihui

Lau, Bonnie W.

Weissman, Bevan S.

Kulaots, Indrek

Yang, Nancy Y. C.

Kane, Agnes B.

Hurt, Robert H. ^{[1
]}

机构：

[1] Brown Univ, Div Engn, Providence, RI 02912 USA

[2] Brown Univ, Dept Chem, Providence, RI 02912 USA

[3] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA

[4] Sandia Natl Labs, Livermore, CA 94551 USA

来源：

ADVANCED MATERIALS | 2006年 / 18卷 / 18期

关键词：

D O I：

10.1002/adma.200600838

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Liquid-crystal self-assembly is used to fabricate carbon nanoparticles specially suited for cell-delivery applications (see figure). The nanoparticles possess high-activity surfaces for easy functionalization and aqueous dispersion, and are shown to be rapidly internalized by mesothelial cells, wherein they show no measurable toxicity relative to crystalline silica used as a positive control.

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页码：2373 / +

页数：7

相关论文

共 42 条

[1] Self-compression and diamond formation in carbon onions [J].

Banhart, F ;

Ajayan, PM .

ADVANCED MATERIALS, 1997, 9 (03) :261-&

[2] Biomedical applications of functionalised carbon nanotubes [J].

Bianco, A ;

Kostarelos, K ;

Partidos, CD ;

Prato, M .

CHEMICAL COMMUNICATIONS, 2005, (05) :571-577

[3]

Bobrov Y, 2001, MOL MATER, V14, P191

[4] Nanoparticle and targeted systems for cancer therapy [J].

Brannon-Peppas, L ;

Blanchette, JO .

ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (11) :1649-1659

[5] Liquid crystal engineering of carbon nanofibers and nanotubes [J].

Chan, C ;

Crawford, G ;

Gao, YM ;

Hurt, R ;

Jian, KQ ;

Li, H ;

Sheldon, B ;

Sousa, M ;

Yang, N .

CARBON, 2005, 43 (12) :2431-2440

[6] Synthesis of magnetic nano-composite particles [J].

Chen, CP ;

Chang, TH ;

Wang, TF .

CERAMICS INTERNATIONAL, 2002, 28 (08) :925-930

[7] Bifunctional carbon nanotubes by sidewall protection [J].

Chopra, N ;

Majumder, M ;

Hinds, BJ .

ADVANCED FUNCTIONAL MATERIALS, 2005, 15 (05) :858-864

[8] Microstructural changes induced in "stacked cup" carbon nanofibers by heat treatment [J].

Endo, M ;

Kim, YA ;

Hayashi, T ;

Yanagisawa, T ;

Muramatsu, H ;

Ezaka, M ;

Terrones, H ;

Terrones, M ;

Dresselhaus, MS .

CARBON, 2003, 41 (10) :1941-1947

[9] Mechanics of receptor-mediated endocytosis [J].

Gao, HJ ;

Shi, WD ;

Freund, LB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (27) :9469-9474

[10] Simple solid-phase synthesis of hollow graphitic nanoparticles and their application to direct methanol fuel cell electrodes [J].

Han, SJ ;

Yun, YK ;

Park, KW ;

Sung, YE ;

Hyeon, T .

ADVANCED MATERIALS, 2003, 15 (22) :1922-+

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