Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract

被引：12

作者：

Almahmeed, T

Boyle, JO

Cohen, EG

Carew, JF

Du, BH

Altorki, NK

Kopelovich, L

Fang, JL

Lazarus, P

Subbaramaiah, K

Dannenberg, AJ ^{[1
]}

机构：

[1] Cornell Univ, Dept Med, Weill Med Coll, New York, NY 10021 USA

[2] Strang Canc Prevent Ctr, New York, NY 10021 USA

[3] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Div Canc Control, Tampa, FL 33612 USA

[4] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Div Mol Oncol, Tampa, FL 33612 USA

[5] NCI, CADRG, DCP, Bethesda, MD 20892 USA

[6] Cornell Univ, Weill Med Coll, Dept Cardiothorac Surg, New York, NY 10021 USA

[7] Cornell Univ, Weill Med Coll, Dept Otorhinolaryngol, New York, NY 10021 USA

[8] Mem Sloan Kettering Canc Ctr, Head & Neck Serv, Dept Surg, New York, NY 10021 USA

来源：

CARCINOGENESIS | 2004年 / 25卷 / 05期

关键词：

D O I：

10.1093/carcin/bgh078

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10. © Oxford University Press 2004; all rights reserved.

引用

页码：793 / 799

页数：7

共 45 条

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INDUCTION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION IN SYNOVIAL FIBROBLASTS BY PROSTAGLANDIN-E AND INTERLEUKIN-1 - A POTENTIAL MECHANISM FOR INFLAMMATORY ANGIOGENESIS [J].