In vitro antiplasmodial activity of extracts of Alchornea cordifolia and identification of an active constituent:: ellagic acid

被引：84

作者：

Banzouzi, JT

Prado, R

Menan, H

Valentin, A

Roumestan, C

Mallie, M

Pelissier, Y

Blache, Y

机构：

[1] Fac Pharm Montpellier, Lab Chim Organ Pharmaceut, EA 2414, F-34060 Montpellier 2, France

[2] UFR Sci Pharmaceut & Biol, Lab Pharmacognosie, F-34060 Montpellier 2, France

[3] Ctr Biochim Struct, F-34060 Montpellier 2, France

[4] UFR Sci Pharmaceut & Biol, Lab Immunol & Parasitol, F-34060 Montpellier 2, France

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2002年 / 81卷 / 03期

关键词：

Alchornea cordifolia; antiplasmodial; ellagic acid;

D O I：

10.1016/S0378-8741(02)00121-6

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Extracts of leaves of Alchornea cordifolia were studied for their antiplasmodial activities. Chloroformic and ether extracts were found to be inactive while the ethanolic extract exhibited mild in vitro activity against Plasinodium falcipartum. Fractionation of this extract led us to isolate ellagic acid as the active constituent of the extract with IC50 in the range of 0.2-0.5 muM. Cytotoxicity of ethanolic fraction and ellagic acid was also estimated on human fibroblasts cells (IC50 on Hela cells = 7.3 muM at 24 It for ellagic acid). (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：399 / 401

页数：3

共 12 条

[1] QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE [J].