In vitro evaluation of electrospun PLGA/PLLA/PDLLA blend fibers loaded with naringin for guided bone regeneration

被引:19
作者
Guo, Zhenzhao [1 ,2 ]
Wu, Shuai [1 ]
Li, Hong [1 ]
Li, Qiyan [3 ,4 ]
Wu, Gang [5 ]
Zhou, Changren [1 ]
机构
[1] Jinan Univ, Dept Mat Sci & Engn, Guangzhou 510632, Guangdong, Peoples R China
[2] Jinan Univ, Affiliated Hosp 1, Guangzhou 510632, Guangdong, Peoples R China
[3] First Peoples Hosp Yunnan Prov, Dept Endodont Periodont & Oral Med, Kunming 650032, Yunnan, Peoples R China
[4] Kunming Univ Sci & Technol, Affiliated Hosp, Dept Endodont Periodont & Oral Med, Kunming 650032, Yunnan, Peoples R China
[5] South China Univ Technol, Dept Biomed Engn, Guangzhou 510641, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Electrospinning; Naringin; PLGA/PLLA/PDLLA; Guided bone regeneration; RELEASE; METRONIDAZOLE; DEGRADATION; SCAFFOLDS; MEMBRANE; DELIVERY; HYBRID; ACID);
D O I
10.4012/dmj.2016-220
中图分类号
R78 [口腔科学];
学科分类号
100302 [口腔临床医学];
摘要
The present study was to evaluate fiber mesh loaded with naringin via electrospinning to guide bone regeneration in vitro. The naringin-loaded fiber mesh was prepared via elctrospinning of PLGA, PLLA, PDLLA blending solution with naringin. SEM showed that naringin decreased the fiber's diameter according to the concentration of naringin. After 20 days' degradation in PBS, the drug loaded fiber meshes still kept their stability with about 10% decrease in tensile strength. In vitro release experiments showed a sustained and steady naringin releasing profile with little initial burst releasing. Compared to the mats without naringin, the fiber mats loaded with naringin showed the most pronounced enhancement of cell growth when MC3T3-E1 cells were cultured on the fiber mats. The blend fiber loaded with naringin has optimized physical properties and sustained release profile in vitro. The study presents a promising fibrous mesh material for guided bone regeneration therapy.
引用
收藏
页码:317 / 324
页数:8
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