A case-control study provides evidence of association for a functional polymorphism-197C/G in XBP1 to schizophrenia and suggests a sex-dependent effect

被引：40

作者：

Chen, WY

Duan, SW

Zhou, J

Sun, Y

Zheng, YL

Gu, NF

Feng, GY

He, L

机构：

[1] Shanghai Jiao Tong Univ, Bio X Life Sci Res Ctr, Shanghai 200030, Peoples R China

[2] Chinese Acad Sci, SIBS, Inst Nutrit Sci, Shanghai 200031, Peoples R China

[3] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 319卷 / 03期

基金：

中国国家自然科学基金;

关键词：

schizophrenia; bipolar disorder; XBP1; functional polymorphism; shared genetic risk; sex;

D O I：

10.1016/j.bbrc.2004.05.060

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Schizophrenia and bipolar disorder are two major psychiatric illnesses that may share specific genetic risk factors to a certain extent. Increasing evidence suggests that the two disorders might be more closely related than previously considered. In order to test this hypothesis, we investigated a functional polymorphism -197C/G in XBP1, which was reported to increase the risk of bipolar disorder, in a case-control study (374 cases vs. 371 controls) to evaluate its genetic role in the pathogenesis of schizophrenia. In the present study, this polymorphism was found to be associated with schizophrenia both at allele (P = 0.034; OR = 1.26, 95% CI 1.02-1.55) and genotype levels (GG vs. CG + CC, 47.59% vs. 38.81%; P = 0.016, df = 1; OR = 1.43, 95% CI 1.07-1.92). Our current data suggest that -197C/G in XBP1 is also a genetic risk factor for schizophrenia. In addition, it presents a sex-dependent genetic effect for the disorder. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：866 / 870

页数：5

共 19 条

[1] Genetics of schizophrenia and the new millennium: Progress and pitfalls [J].

Baron, M .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (02) :299-312

[2] Susceptibility loci for bipolar disorder: Overlap with inherited vulnerability to schizophrenia [J].

Berrettini, WH .

BIOLOGICAL PSYCHIATRY, 2000, 47 (03) :245-251

[3]

Bouras T, 2002, CANCER RES, V62, P1289

[4] Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia [J].

Chumakov, I ;

Blumenfeld, M ;

Guerassimenko, O ;

Cavarec, L ;

Palicio, M ;

Abderrahim, H ;

Bougueleret, L ;

Barry, C ;

Tanaka, H ;

La Rosa, P ;

Puech, A ;

Tahri, N ;

Cohen-Akenine, A ;

Delabrosse, S ;

Lissarrague, S ;

Picard, FP ;

Maurice, K ;

Essioux, L ;

Millasseau, P ;

Grel, P ;

Debailleul, V ;

Simon, AM ;

Caterina, D ;

Dufaure, I ;

Malekzadeh, K ;

Belova, M ;

Luan, JJ ;

Bouillot, M ;

Sambucy, JL ;

Primas, G ;

Saumier, M ;

Boubkiri, N ;

Martin-Saumier, S ;

Nasroune, M ;

Peixoto, H ;

Delaye, A ;

Pinchot, V ;

Bastucci, M ;

Guillou, S ;

Chevillon, M ;

Sainz-Fuertes, R ;

Meguenni, S ;

Aurich-Costa, J ;

Cherif, D ;

Gimalac, A ;

Van Duijn, C ;

Gauvreau, D ;

Quelette, G ;

Fortier, I ;

Realson, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13675-13680

[5] The basic domain leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core [J].

Clauss, IM ;

Chu, M ;

Zhao, JL ;

Glimcher, LH .

NUCLEIC ACIDS RESEARCH, 1996, 24 (10) :1855-1864

[6] RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer [J].

Finlin, BS ;

Gau, CL ;

Murphy, GA ;

Shao, HP ;

Kimel, T ;

Seitz, RS ;

Chiu, YF ;

Botstein, D ;

Brown, PO ;

Tamanoi, F ;

Andres, DA ;

Perou, CM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (45) :42259-42267

[7] 'Unfolding' pathways in neurodegenerative disease [J].

Forman, MS ;

Lee, VMY ;

Trojanowski, JQ .

TRENDS IN NEUROSCIENCES, 2003, 26 (08) :407-410

[8] Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series [J].

Hattori, E ;

Liu, CY ;

Badner, JA ;

Bonner, TI ;

Christian, SL ;

Maheshwari, M ;

Detera-Wadleigh, SD ;

Gibbs, RA ;

Gershon, ES .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (05) :1131-1140

[9] Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects [J].

Hennah, W ;

Varilo, T ;

Kestilä, M ;

Paunio, T ;

Arajärvi, R ;

Haukka, J ;

Parker, A ;

Martin, R ;

Levitzky, S ;

Partonen, T ;

Meyer, J ;

Lönnqvist, J ;

Peltonen, L ;

Ekelund, J .

HUMAN MOLECULAR GENETICS, 2003, 12 (23) :3151-3159

[10] Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder [J].

Kakiuchi, C ;

Iwamoto, K ;

Ishiwata, M ;

Bundo, M ;

Kasahara, T ;

Kusumi, I ;

Tsujita, T ;

Okazaki, Y ;

Nanko, S ;

Kunugi, H ;

Sasaki, T ;

Kato, T .

NATURE GENETICS, 2003, 35 (02) :171-175

← 1 2 →