Direct asymmetric aldol reaction catalyzed by nanocrystalline magnesium oxide

被引：47

作者：

Choudary, B. M.

Chakrapani, Lakkoju

Ramani, Thekkathu

Kumar, K. Vijay

Kantam, M. Lakshmi

机构：

[1] Ogene Syst I Pvt Ltd, Hyderabad, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON | 2006年 / 62卷 / 41期

关键词：

direct asymmetric aldol reaction; NAP-MgO; enantiomeric excess; beta-hydroxy carbonyl compounds;

D O I：

10.1016/j.tet.2006.07.091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nanomaterials with their three-dimensional structure and defined size and shape are considered to be suitable candidates for proper alignment with prochiral substrates for unidirectional introduction of reacting species to induce an asymmetric centre. The reusable and suitably aligned nanocrystalline magnesium oxide catalyzed direct asymmetric aldol reaction afforded the chiral beta-hydroxy carbonyl compounds in good yields and moderate ee's. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：9571 / 9576

页数：6

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