Regulation of Plant Stem Cell Quiescence by a Brassinosteroid Signaling Module

被引：144

作者：

Vilarrasa-Blasi, Josep ^{[1
]}

Gonzalez-Garcia, Mary-Paz ^{[1
]}

Frigola, David ^{[2
]}

Fabregas, Norma ^{[1
]}

Alexiou, Konstantinos G. ^{[1
]}

Lopez-Bigas, Nuria ^{[3
]}

Rivas, Susana ^{[4
,5
]}

Jauneau, Alain ^{[6
]}

Lohmann, Jan U. ^{[7
]}

Benfey, Philip N. ^{[8
,9
]}

Ibanes, Marta ^{[2
]}

Cano-Delgado, Ana I. ^{[1
]}

机构：

[1] CSIC IRTA UAB UB, CRAG, Dept Mol Genet, Barcelona 08193, Spain

[2] Univ Barcelona, Fac Fis, Dept Estruct & Constituents Mat, E-08028 Barcelona, Spain

[3] Barcelona Biomed Res Pk PRBB, Res Unit Biomed Informat GRIB, Biomed Genom Grp, Barcelona 08003, Spain

[4] INRA, LIPM, UMR441, F-31326 Castanet Tolosan, France

[5] CNRS, UMR2594, LIPM, F-31326 Castanet Tolosan, France

[6] Federat Rech 3450, Plateforme Imagerie, Pole Biotechnol Vegetale, F-31320 Castanet Tolosan, France

[7] Heidelberg Univ, COS, D-69120 Heidelberg, Germany

[8] Duke Univ, HHMI, Dept Biol, Durham, NC 27708 USA

[9] Duke Univ, Duke Ctr Syst Biol, Durham, NC 27708 USA

来源：

DEVELOPMENTAL CELL | 2014年 / 30卷 / 01期

关键词：

GENE-EXPRESSION; ARABIDOPSIS; DIVISION; DIFFERENTIATION; REVEALS; NETWORK; GROWTH; CANCER; NICHE; SHOOT;

D O I：

10.1016/j.devcel.2014.05.020

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The quiescent center (QC) maintains the activity of the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaining the low rate of QC cell division remain poorly understood. Here, we identified a R2R3-MYB transcription factor, BRAVO (BRASSINOSTEROIDS AT VASCULAR AND ORGANIZING CENTER), acting as a cell-specific repressor of QC divisions in the primary root of Arabidopsis. Ectopic BRAVO expression restricts overall root growth and ceases root regeneration upon damage of the stem cells, demonstrating the role of BRAVO in counteracting Brassinosteroid (BR)-mediated cell division in the QC cells. Interestingly, BR-regulated transcription factor BES1 (BRI1-EMS SUPRESSOR 1) directly represses and physically interacts with BRAVO in vivo, creating a switch that modulates QC divisions at the root stem cell niche. Together, our results define a mechanism for BR-mediated regulation of stem cell quiescence in plants.

引用

页码：36 / 47

页数：12

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