Vagus nerve stimulation therapy, epilepsy, and device parameters - Scientific basis and recommendations for use

被引：124

作者：

Heck, C

Helmers, SL

DeGiorgio, CM

机构：

[1] Univ Calif Los Angeles, Dept Neurol, Reed Neurol Res Ctr, Los Angeles, CA 90024 USA

[2] Keck Sch Med, USC Dept Neurol, Los Angeles, CA USA

[3] Emory Univ, Sch Med, Atlanta, GA USA

来源：

NEUROLOGY | 2002年 / 59卷 / 06期

关键词：

D O I：

10.1212/WNL.59.6_suppl_4.S31

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Our understanding of a precise dose-response relationship for vagus nerve stimulation (VNS) therapy in the treatment of seizures is still evolving. Because several parameters are involved in VNS therapy, the individual contribution of each is not well understood. This review discusses the efficacy of stimulation parameters used in the VNS clinical trials. The background, influence on safety and efficacy, and role in helping to achieve seizure control are discussed for each VNS device parameter: output current, pulse duration, frequency, and duty cycle. Finally, we provide an algorithm for the adjustment of VNS device settings (see Appendices).

引用

页码：S31 / S37

页数：7

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