ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics

被引：794

作者：

Arteaga, Carlos L. ^{[1
]}

Engelman, Jeffrey A. ^{[2
]}

机构：

[1] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

来源：

CANCER CELL | 2014年 / 25卷 / 03期

关键词：

EPIDERMAL-GROWTH-FACTOR; TYROSINE KINASE INHIBITOR; CELL LUNG-CANCER; ADVANCED BREAST-CANCER; GENE COPY NUMBER; PERTUZUMAB PLUS TRASTUZUMAB; FACTOR-I RECEPTOR; ACQUIRED-RESISTANCE; NEOADJUVANT CHEMOTHERAPY; ADJUVANT TRASTUZUMAB;

D O I：

10.1016/j.ccr.2014.02.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ERBB receptors were linked to human cancer pathogenesis approximately three decades ago. Biomedical investigators have since developed substantial understanding of the biology underlying the dependence of cancers on aberrant ERBB receptor signaling. An array of cancer-associated genetic alterations in ERBB receptors has also been identified. These findings have led to the discovery and development of mechanism-based therapies targeting ERBB receptors that have improved outcome for many cancer patients. In this Perspective, we discuss current paradigms of targeting ERBB receptors with cancer therapeutics and our understanding of mechanisms of action and resistance to these drugs. As current strategies still have limitations, we also discuss challenges and opportunities that lie ahead as basic scientists and clinical investigators work toward more breakthroughs.

引用

页码：282 / 303

页数：22

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