Chiral lithium amides on solid support: synthesis and applications in enantioselective deprotonation of cyclic ketones

被引：19

作者：

Majewski, M ^{[1
]}

Ulaczyk, A ^{[1
]}

Wang, F ^{[1
]}

机构：

[1] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 5C9, Canada

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 50期

关键词：

enantioselection; deprotonation; amines; polymer support;

D O I：

10.1016/S0040-4039(99)01882-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several chiral amines attached to polymer support (Merrifield resin or a soluble analog) are described. Lithium amides, generated from these amines by treatment with BuLi, react with C(S)-symmetrical ketones to give the corresponding enolates enantioselectively (ee up to 75%). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8755 / 8758

页数：4

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