HIV Associated Neurocognitive Disorders in the Modern Antiviral Treatment Era: Prevalence, Characteristics, Biomarkers, and Effects of Treatment

被引：65

作者：

Chan, Phillip ^{[5
,6
]}

Brew, Bruce J. ^{[1
,2
,3
,4
]}

机构：

[1] Univ New S Wales, St Vincents Clin Sch, Sydney, NSW, Australia

[2] St Vincents Hosp, Dept Neurol, Sydney, NSW 2010, Australia

[3] St Vincents Hosp, HIV Dept, Sydney, NSW 2010, Australia

[4] St Vincents Hosp, Ctr Applied Med Res, Sydney, NSW 2010, Australia

[5] Queen Elizabeth Hosp, Dept Internal Med, Neurol team, Hong Kong, Hong Kong, Peoples R China

[6] St Vincents Hosp, Dept Neurol, Darlinghurst, NSW 2010, Australia

来源：

CURRENT HIV/AIDS REPORTS | 2014年 / 11卷 / 03期

关键词：

HIV; cART; Cognitive impairment; HAND; CPE; CNS; HUMAN-IMMUNODEFICIENCY-VIRUS; COMBINATION ANTIRETROVIRAL THERAPY; CNS PENETRATION-EFFECTIVENESS; WHITE-MATTER ABNORMALITIES; CEREBROSPINAL-FLUID; COGNITIVE IMPAIRMENT; IMMUNE ACTIVATION; INFECTED PATIENTS; APOE EPSILON-4; DEMENTIA SCALE;

D O I：

10.1007/s11904-014-0221-0

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

The introduction of combination antiretroviral treatment (cART) has significantly reduced the mortality secondary to opportunistic infections in HIV patients by restoring the immune system. In the central nervous system (CNS), there has also been benefit with a marked reduction of HIV associated dementia. However, the milder forms of HIV associated neurocognitive disorder (HAND), namely asymptomatic neurocognitive impairment and mild neurocognitive disorder, remain prevalent in the cART era. In this article, we will discuss how cART interacts with HAND in terms of clinical characteristics and biomarkers. We will then review the outcomes of recent clinical studies focused on the CNS penetrating antiretroviral regimens and some novel therapeutic approaches.

引用

页码：317 / 324

页数：8

共 89 条

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