Dimerization of resveratrol by the grapevine pathogen Botrytis cinerea

被引:114
作者
Cichewicz, RH
Kouzi, SA [1 ]
Hamann, MT
机构
[1] Univ Louisiana Monroe, Sch Pharm, Div Basic Pharmaceut Sci, Monroe, LA 71209 USA
[2] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA
来源
JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 01期
关键词
D O I
10.1021/np990266n
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Resveratrol (trans-3,4',5-trihydroxystilbene) is produced by grapes (Vitis spp.) in response to microbial attack by the fungal grapevine pathogen Botrytis cinerca. Several reports indicate that pathogenic B. cinerca strains are capable of biotransforming resveratrol into an assortment of unidentified oxidized metabolites as a means of reducing the antifungal effects of resveratrol and facilitating Botrytis invasion into host-plant tissues. Studies utilizing growing incubations of Botrytis cinerea ATCC 11542 with resveratrol resulted in the production of three new (restrytisols A-C) (1-3) and three known (resveratrol trans-dehydrodimer, leachinol F, and pallidol) oxidized resveratrol dimers. All of the metabolites were evaluated for their anti-HIV-1, cytotoxic, and cyclooxygenase (COX) I and COX II inhibitory activities.
引用
收藏
页码:29 / 33
页数:5
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