Molecular tumor markers for asbestos-related mesothelioma: Serum diagnostic markers

被引：38

作者：

Maeda, Masahiro

Hino, Okio

机构：

[1] Juntendo Univ, Sch Med, Dept Pathol, Bunkyo Ku, Tokyo 1138421, Japan

[2] Immunobiol Labs, Gunma, Japan

来源：

PATHOLOGY INTERNATIONAL | 2006年 / 56卷 / 11期

关键词：

asbestos; ELISA; ERC/mesothelin/MPF; mesothelioma; tumor marker;

D O I：

10.1111/j.1440-1827.2006.02024.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Mesothelioma is an aggressive tumor arising from the mesothelium, and is usually associated with previous exposure to asbestos. The incubation period of the tumor may be described as 30-40 years, and the prognosis is dismal. In addition to immunohistochemical markers, recently, serum markers for the diagnosis of mesothelioma have been reported as candidates. In contrast, the expression in renal carcinoma (ERC) gene has been discovered in the Eker rat model (Tsc2 gene mutant), which is a homolog of the human mesothelin/megakaryocyte potentiating factor gene, and a novel ELISA system (N-ERC/mesothelin) has been developed. It has also been found that N-ERC/mesothelin is very stable and plentiful in the blood. In the present paper the potential utility of molecular diagnostic markers is reviewed, including ELISA systems for asbestos-related mesothelioma.

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收藏

页码：649 / 654

页数：6

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