Practical management of bleeding due to the anticoagulants dabigatran, rivaroxaban, and apixaban

被引：43

作者：

Fawole, Adewale ^{[1
]}

Daw, Hamed A. ^{[2
,3
]}

Crowther, Mark A. ^{[4
,5
,6
]}

机构：

[1] Fairview Hosp, Dept Internal Med, Cleveland, OH USA

[2] Fairview Hosp, Cleveland Clin, Ctr Canc, Cleveland, OH USA

[3] Case Western Reserve Univ, Cleveland Clin, Lerner Coll Med, Cleveland, OH 44106 USA

[4] McMaster Univ, Div Hematol & Thromboembolism, Hamilton, ON, Canada

[5] Hamilton Reg Lab Med Program, Lab Med, Hamilton, ON, Canada

[6] McMaster Univ, Hamilton, ON L8S 4L8, Canada

来源：

CLEVELAND CLINIC JOURNAL OF MEDICINE | 2013年 / 80卷 / 07期

关键词：

DIRECT THROMBIN INHIBITOR; FACTOR-XA INHIBITOR; PROTHROMBIN COMPLEX CONCENTRATE; INTERNATIONAL NORMALIZED RATIO; ATRIAL-FIBRILLATION; PLASMA-CONCENTRATIONS; AMERICAN-COLLEGE; REVERSAL AGENTS; IN-VITRO; PHARMACOKINETICS;

D O I：

10.3949/ccjm.80a.13025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The new oral anticoagulants dabigatran etexilate (Pradaxa), rivaroxaban (Xarelto), and apixaban (Eliquis) have predictable pharmacokinetic and pharmacodynamic profiles and are alternatives to warfarin. However, many physicians are wary of these drugs, since there is limited evidence on how to manage bleeding in patients taking them, and since no specific antidote is known to reverse their anticoagulant effect. Management requires careful adherence to first principles of bleeding care. Unapproved and untested reversal strategies may be required in patients with life-threatening bleeding.

引用

页码：443 / 451

页数：9

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