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The roles of TLRs, RLRs and NLRs in pathogen recognition

被引：1198
作者：
Kawai, Taro [1 ,2 ]
Akira, Shizuo [1 ,2 ]
机构：
[1] World Premier Int Res Ctr, Immunol Frontier Res Ctr, Host Def Lab, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, Japan
来源：
INTERNATIONAL IMMUNOLOGY | 2009年 / 21卷 / 04期
关键词：
innate immunity; NOD-like receptor; RIG-I-like receptor; signal transduction; Toll-like receptor; TOLL-LIKE RECEPTOR; NF-KAPPA-B; PLASMACYTOID DENDRITIC CELLS; INNATE IMMUNE RECOGNITION; SINGLE-STRANDED RNA; BACTERIAL MURAMYL DIPEPTIDE; INTERFERON-ALPHA PRODUCTION; GENOME-WIDE ASSOCIATION; ADAPTER PROTEIN CARD9; NOD-LIKE RECEPTORS;
D O I：
10.1093/intimm/dxp017
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The mammalian innate immune system detects the presence of microbial infection through germ line-encoded pattern recognition receptors (PRRs). Toll-like receptors, retinoic acid-inducible gene-I-like receptors and nucleotide-binding oligomerization domain-like receptors serve as PRRs that recognize different but overlapping microbial components. They are expressed in different cellular compartments such as the cell surface, endosome, lysosome or cytoplasm and activate specific signaling pathways that lead to expression of genes that tailor immune responses to particular microbes. This review summarizes recent insights into pathogen sensing by these PRRs and their signaling pathways.
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页码：317 / 337
页数：21
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