Evaluation of a molecularly imprinted polymer for the isolation/enrichment of β-estradiol

被引：32

作者：

Celiz, Mary Dawn ^{[1
]}

Aga, Diana S. ^{[1
]}

Colon, Luis A. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

MICROCHEMICAL JOURNAL | 2009年 / 92卷 / 02期

基金：

美国国家科学基金会;

关键词：

Molecularly imprinted polymer; Estradiol; Solid phase extraction; Molecular imprinting; SOLID-PHASE EXTRACTION; WASTE-WATER TREATMENT; PRECIPITATION POLYMERIZATION; POLY(DIVINYLBENZENE) MICROSPHERES; STATIONARY-PHASE; LIQUID-CHROMATOGRAPHY; ESTROGENIC COMPOUNDS; STEROID ESTROGENS; MASS-SPECTROMETRY; RIVER WATER;

D O I：

10.1016/j.microc.2009.03.007

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The selective preconcentration of estradiol was explored using the recognition ability of a molecularly imprinted polymer(MIP) in the solid phase extraction (SPE) format. Polymeric particles were imprinted with 17 beta-estradiol using methacrylic acid as functional monomer and divinylbenzene as crosslinker. Binding studies of these polymeric particles towards 17 beta-estraidiol showed selectivity over non-imprinted polymers, using acetonitrile as solvent. The imprinted polymer showed a recovery of 88% for beta-estradiol in deionized water and 81% in surface water. The selectivity of the MIP over the non-imprinted polymer was relatively low, only 10% higher recovery. The results indicate that the MIP imprinted with 17 beta-estradiol does not appear to provide a viable approach to be used in a sample clean-up or enrichment step for the determination of estradiol in aqueous systems. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：174 / 179

页数：6

共 58 条

[1] Molecular imprinting: developments and applications in the analytical chemistry field [J].