Synthesis and resolution of 2-methyl-Quinazolinap, a new atropisomeric phosphinamine ligand for asymmetric catalysis

被引：46

作者：

Lacey, PM ^{[1
]}

McDonnell, CM ^{[1
]}

Guiry, PJ ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Dublin, Dept Chem, Dublin 4, Ireland

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(00)00183-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation in a five-step sequence of 2-methyl-Quinazolinap, a new atropisomeric ligand for asymmetric catalysis, is described. Diastereomeric palladacycles derived from racemic ligand and (+)-di-mu-chlorobis[(R)-dimethyl(1-( 1-naphthyl)ethyl)aminato-C-2,N]dipalladium(II) were separated by fractional crystallisation. Displacement of the resolving agent by reaction with DPPE afforded enantiopure 2-methyl-Quinazolinap. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2475 / 2478

页数：4