Effects of autologous stem cell transplantation on ventricular electrophysiology in doxorubicin-induced heart failure

被引：34

作者：

Chen, Mao ^{[1
]}

Fan, Zhong-Cai

Liu, Xiao-Jing

Deng, Jue-Lin

Zhang, Li

Rao, Li

Yang, Qing

Huang, De-Jia

机构：

[1] Sichuan Univ, W China Hosp, Dept Cardiol, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, W China Hosp, Cardiovasc Res Lab, Chengdu 610041, Sichuan, Peoples R China

来源：

CELL BIOLOGY INTERNATIONAL | 2006年 / 30卷 / 07期

基金：

中国国家自然科学基金;

关键词：

stem cells; transplantation; heart failure; electrophysiology; conduction;

D O I：

10.1016/j.cellbi.2006.03.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To investigate whether stem cell transplantation affects ventricular electrophysiology in vivo, either autologous bone marrow mesenchymal stem cells or skeletal myoblast cells were transplanted via a catheter into a doxorubicin-treated failing heart. Four weeks after transplantation, electrophysiological investigation showed that transplantation of either cell type prolonged the local activation time and increased the activation time dispersion. In the stem cell transplantation groups, a positive correlation was demonstrated between activation time dispersion and the number of stem cell-derived cells in the pacing site. It is concluded that transplantation of either mesenchymal stem cells or skeletal myoblast cells might exacerbate abnormalities of local ventricular conduction in the doxorubicin-treated failing heart. (c) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

引用

页码：576 / 582

页数：7

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