Effects of autologous stem cell transplantation on ventricular electrophysiology in doxorubicin-induced heart failure

被引：34

作者：

Chen, Mao ^{[1
]}

Fan, Zhong-Cai

Liu, Xiao-Jing

Deng, Jue-Lin

Zhang, Li

Rao, Li

Yang, Qing

Huang, De-Jia

机构：

[1] Sichuan Univ, W China Hosp, Dept Cardiol, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, W China Hosp, Cardiovasc Res Lab, Chengdu 610041, Sichuan, Peoples R China

来源：

CELL BIOLOGY INTERNATIONAL | 2006年 / 30卷 / 07期

基金：

中国国家自然科学基金;

关键词：

stem cells; transplantation; heart failure; electrophysiology; conduction;

D O I：

10.1016/j.cellbi.2006.03.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To investigate whether stem cell transplantation affects ventricular electrophysiology in vivo, either autologous bone marrow mesenchymal stem cells or skeletal myoblast cells were transplanted via a catheter into a doxorubicin-treated failing heart. Four weeks after transplantation, electrophysiological investigation showed that transplantation of either cell type prolonged the local activation time and increased the activation time dispersion. In the stem cell transplantation groups, a positive correlation was demonstrated between activation time dispersion and the number of stem cell-derived cells in the pacing site. It is concluded that transplantation of either mesenchymal stem cells or skeletal myoblast cells might exacerbate abnormalities of local ventricular conduction in the doxorubicin-treated failing heart. (c) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

引用

页码：576 / 582

页数：7

共 25 条

[11] Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction [J].

Menasché, P ;

Hagège, AA ;

Vilquin, JT ;

Desnos, M ;

Abergel, E ;

Pouzet, B ;

Bel, A ;

Sarateanu, S ;

Scorsin, M ;

Schwartz, K ;

Bruneval, P ;

Benbunan, M ;

Marolleau, JP ;

Duboc, D .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (07) :1078-1083

[12] Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect [J].

Papadaki, HA ;

Kritikos, HD ;

Gemetzi, C ;

Koutala, H ;

Marsh, JCW ;

Boumpas, DT ;

Eliopoulos, GD .

BLOOD, 2002, 99 (05) :1610-1619

[13] Stem-cell therapy after acute myocardial infarction: the focus should be on those at risk [J].

Penn, MS .

LANCET, 2006, 367 (9505) :87-88

[14] Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure [J].

Perin, EC ;

Dohmann, HFR ;

Borojevic, R ;

Silva, SA ;

Sousa, ALS ;

Mesquita, CT ;

Rossi, MID ;

Carvalho, AC ;

Dutra, HS ;

Dohmann, HJF ;

Silva, GV ;

Belém, L ;

Vivacqua, R ;

Rangel, FOD ;

Esporcatte, R ;

Geng, YJ ;

Vaughn, WK ;

Assad, JAR ;

Mesquita, ET ;

Willerson, JT .

CIRCULATION, 2003, 107 (18) :2294-2302

[15] Chronic cardiotoxicity of anticancer anthracyclines in the rat: role of secondary metabolites and reduced toxicity by a novel anthracycline with impaired metabolite formation and reactivity [J].

Sacco, G ;

Giampietro, R ;

Salvatorelli, E ;

Menna, P ;

Bertani, N ;

Graiani, G ;

Animati, F ;

Goso, C ;

Maggi, CA ;

Manzini, S ;

Minotti, G .

BRITISH JOURNAL OF PHARMACOLOGY, 2003, 139 (03) :641-651

[16] Transcoronary implantation of bone marrow stromal cells ameliorates cardiac function after myocardial infarction [J].

Saito, T ;

Kuang, JG ;

Lin, CCH ;

Chiu, RCJ .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2003, 126 (01) :114-123

[17] Comparison of the effects of fetal cardiomyocyte and skeletal myoblast transplantation on postinfarction left ventricular function [J].

Scorsin, M ;

Hagège, A ;

Vilquin, JT ;

Fiszman, M ;

Marotte, F ;

Samuel, JL ;

Rappaport, L ;

Schwartz, K ;

Menasché, P .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2000, 119 (06) :1169-1175

[18] Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure - Clinical experience with six-month follow-up [J].

Smits, PC ;

van Geuns, RJM ;

Poldermans, D ;

Bountioukos, M ;

Onderwater, EEM ;

Lee, CH ;

Maat, APWM ;

Serruys, PW .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 42 (12) :2063-2069

[19] Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans [J].

Strauer, BE ;

Brehm, M ;

Zeus, T ;

Köstering, M ;

Hernandez, A ;

Sorg, RV ;

Kögler, G ;

Wernet, P .

CIRCULATION, 2002, 106 (15) :1913-1918

[20]

Suzuki K, 2001, CIRCULATION, V104, pI213

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