Reflections on CD8 T-cell activation and memory

被引：40

作者：

Masopust, D

Ahmed, R

机构：

[1] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

来源：

IMMUNOLOGIC RESEARCH | 2004年 / 29卷 / 1-3期

关键词：

immunological memory; T-cell immunity; cytotoxic T-cells; viral immunity; CD8 T-cell differentiation;

D O I：

10.1385/IR:29:1-3:151

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8 T cells contribute to clearance and long-term protection following acute infection with certain viruses, bacteria, and protozoa, and may play an important role in tumor immunity. Primary adaptive CD8 T-cell responses have been conceptually divided into four phases: activation, expansion, contraction, and memory. We summarize each phase of the response, and discuss recent advances in our understanding of the development and maintenance of CD8 T-cell memory.

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收藏

页码：151 / 160

页数：10

相关论文

共 71 条

[1] Immunological memory and protective immunity: Understanding their relation [J].

Ahmed, R ;

Gray, D .

SCIENCE, 1996, 272 (5258) :54-60

[2] LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION IS ASSOCIATED WITH LONG-STANDING PERTURBATION OF LFA-1 EXPRESSION ON CD8(+) T-CELLS [J].

ANDERSSON, EC ;

CHRISTENSEN, JP ;

SCHEYNIUS, A ;

MARKER, O ;

THOMSEN, AR .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1995, 42 (01) :110-118

[3] CD28 INTERACTION WITH B7-COSTIMULATES PRIMARY ALLOGENEIC PROLIFERATIVE RESPONSES AND CYTOTOXICITY MEDIATED BY SMALL, RESTING LYMPHOCYTES-T [J].

AZUMA, M ;

CAYABYAB, M ;

BUCK, D ;

PHILLIPS, JH ;

LANIER, LL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (02) :353-360

[4]

Bachmann MF, 2001, EUR J IMMUNOL, V31, P450, DOI 10.1002/1521-4141(200102)31:2<450::AID-IMMU450>3.0.CO

[5]

2-X

[6] Programmed contraction of CD8+ T cells after infection [J].

Badovinac, VP ;

Porter, BB ;

Harty, JT .

NATURE IMMUNOLOGY, 2002, 3 (07) :619-626

[7] Cutting edge: Rapid in vivo killing by memory CD8 T cells [J].

Barber, DL ;

Wherry, EJ ;

Ahmed, R .

JOURNAL OF IMMUNOLOGY, 2003, 171 (01) :27-31

[8] A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection [J].

Bassiri, H ;

Carding, SR .

JOURNAL OF IMMUNOLOGY, 2001, 166 (10) :5945-5954

[9] Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells [J].

Becker, TC ;

Wherry, EJ ;

Boone, D ;

Murali-Krishna, K ;

Antia, R ;

Ma, A ;

Ahmed, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (12) :1541-1548

[10] The CD8 response on autopilot [J].

Bevan, MJ ;

Fink, PJ .

NATURE IMMUNOLOGY, 2001, 2 (05) :381-382

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