Reflections on CD8 T-cell activation and memory

被引：40

作者：

Masopust, D

Ahmed, R

机构：

[1] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

来源：

IMMUNOLOGIC RESEARCH | 2004年 / 29卷 / 1-3期

关键词：

immunological memory; T-cell immunity; cytotoxic T-cells; viral immunity; CD8 T-cell differentiation;

D O I：

10.1385/IR:29:1-3:151

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8 T cells contribute to clearance and long-term protection following acute infection with certain viruses, bacteria, and protozoa, and may play an important role in tumor immunity. Primary adaptive CD8 T-cell responses have been conceptually divided into four phases: activation, expansion, contraction, and memory. We summarize each phase of the response, and discuss recent advances in our understanding of the development and maintenance of CD8 T-cell memory.

引用

收藏

页码：151 / 160

页数：10

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