SNFing HIV transcription

被引：17

作者：

Bukrinsky, Michael ^{[1
]}

机构：

[1] George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA

来源：

RETROVIROLOGY | 2006年 / 3卷 / 1期

关键词：

D O I：

10.1186/1742-4690-3-49

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The SWI/SNF chromatin remodeling complex is an essential regulator of transcription of cellular genes. HIV-1 infection induces exit of a core component of SWI/SNF, Ini1, into the cytoplasm and its association with the viral pre-integration complex. Several recent papers published in EMBO Journal, Journal of Biological Chemistry, and Retrovirology provide new information regarding possible functions of Ini1 and SWI/SNF in HIV life cycle. It appears that Ini1 has an inhibitory effect on pre-integration steps of HIV replication, but also contributes to stimulation of Tat-mediated transcription. This stimulation involves displacement of the nucleosome positioned at the HIV promoter.

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