Thinking About Broadly Cross-Reactive Vaccines

被引：2

作者：

Doherty, P. C. ^{[1
,2
]}

Turner, S. J. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic, Australia

[2] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2009年 / 85卷 / 06期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

INFLUENZA-A VIRUS; CYTOTOXIC T-LYMPHOCYTES; CELL IMMUNODOMINANCE HIERARCHY; HIV-1; VACCINE; INFECTION; IMMUNITY; MEMORY; ANTIBODY; ESCAPE; RESPONSES;

D O I：

10.1038/clpt.2009.52

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Successful vaccines function almost exclusively by establishing long-lived plasma cells that secrete antibody into the blood and at mucosal sites. Some pathogens, such as HIV and the influenza A viruses, use a mutational strategy to escape neutralization by antibodies specific for surface glycoproteins. The CD8(+) cytotoxic T-lymphocyte (CTL) response is, on the other hand, directed mostly at peptides derived from conserved, internal virus proteins. Can CTL memory be manipulated to provide cross-reactive protection?

引用

页码：665 / 668

页数：4

共 51 条

[11] Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1 [J].

Coles, RM ;

Mueller, SN ;

Heath, WR ;

Carbone, FR ;

Brooks, AG .

JOURNAL OF IMMUNOLOGY, 2002, 168 (02) :834-838

[12] Influenza and the challenge for immunology [J].

Doherty, PC ;

Turner, SJ ;

Webby, RG ;

Thomas, PG .

NATURE IMMUNOLOGY, 2006, 7 (05) :449-455

[13] Toward a broadly protective influenza vaccine [J].

Doherty, Peter C. ;

Kelso, Anne .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (10) :3273-3275

[14] CLEARANCE OF INFLUENZA-VIRUS RESPIRATORY-INFECTION IN MICE LACKING CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED CD8+ T-CELLS [J].

EICHELBERGER, M ;

ALLAN, W ;

ZIJLSTRA, M ;

JAENISCH, R ;

DOHERTY, PC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (04) :875-880

[15] Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: An experiment of nature [J].

Epstein, SL .

JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (01) :49-53

[16] Perspective - HIV vaccine research: The way forward [J].

Fauci, Anthony S. ;

Johnston, Margaret I. ;

Dieffenbach, Carl W. ;

Burton, Dennis R. ;

Hammer, Scott M. ;

Hoxie, James A. ;

Martin, Malcolm ;

Overbaugh, Julie ;

Watkins, David I. ;

Mahmoud, Adel ;

Greene, Warner C. .

SCIENCE, 2008, 321 (5888) :530-532

[17] Influenza vaccination: policy versus evidence - No gap between policy and evidence [J].

Fedson, David S. ;

Nichol, Kristin L. .

BMJ-BRITISH MEDICAL JOURNAL, 2006, 333 (7576) :1020-1020

[18] Virus-specific CD8+ T cells in primary and secondary influenza pneumonia [J].

Flynn, KJ ;

Belz, GT ;

Altman, JD ;

Ahmed, R ;

Woodland, DL ;

Doherty, PC .

IMMUNITY, 1998, 8 (06) :683-691

[19] B Cell Recognition of the Conserved HIV-1 Co-Receptor Binding Site Is Altered by Endogenous Primate CD4 [J].

Forsell, Mattias N. E. ;

Dey, Barna ;

Moerner, Andreas ;

Svehla, Krisha ;

O'dell, Sijy ;

Hoegerkorp, Carl-Magnus ;

Voss, Gerald ;

Thorstensson, Rigmor ;

Shaw, George M. ;

Mascola, John R. ;

Hedestam, Gunilla B. Karlsson ;

Wyatt, Richard T. .

PLOS PATHOGENS, 2008, 4 (10)

[20] Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes [J].

Frahm, N ;

Kiepiela, P ;

Adams, S ;

Linde, CH ;

Hewitt, HS ;

Sango, K ;

Feeney, ME ;

Addo, MM ;

Lichterfeld, M ;

Lahaie, MP ;

Pae, E ;

Wurcel, AG ;

Roach, T ;

St John, MA ;

Altfeld, M ;

Marincola, FM ;

Moore, C ;

Mallal, S ;

Carrington, M ;

Heckerman, D ;

Allen, TM ;

Mullins, JI ;

Korber, BT ;

Goulder, PJR ;

Walker, BD ;

Brander, C .

NATURE IMMUNOLOGY, 2006, 7 (02) :173-178

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