Cytokines in neuroinflammation and Alzheimer's disease

被引：191

作者：

Cacquevel, M ^{[1
]}

Lebeurrier, N ^{[1
]}

Chéenne, S ^{[1
]}

Vivien, D ^{[1
]}

机构：

[1] Univ Caen, UMR 6185, CNRS, Ctr Cyceron, F-14074 Caen, France

来源：

CURRENT DRUG TARGETS | 2004年 / 5卷 / 06期

关键词：

Alzheimer's disease; inflammation; cytokine; TGF-beta;

D O I：

10.2174/1389450043345308

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inflammation has been reported in numerous neurodegenerative disorders such as Parkinson's disease. stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located to the vicinity of amlyloid plaques. Cytokines, such as Interleukin-1 (IL-1), Interleukin-6 (IL-6), Tumor Necrosis Factor alpha (TNF-alpha) and Transforming Growth Factor beta (TGF-beta) have been clearly involved in this inflammatory process. Although their expression is induced by the presence of amyloid-beta peptide, these cytokines are also able to promote the accumulation of amyloid-beta peptide. Altogether, IL-1, IL-6, TNF-alpha and TGT-beta should be considered as key players of a vicious circle leading to the progression of the disease.

引用

页码：529 / 534

页数：6

共 115 条

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