Hysteresis in the glucose permeability versus pH characteristic for a responsive hydrogel membrane

被引:36
作者
Baker, JP
Siegel, RA
机构
[1] School of Pharmacy S-926, University of California, San Francisco
关键词
D O I
10.1002/marc.1996.030170607
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A side-by-side diffusion cell was used to study the permeability of glucose through a temperature- and pH-sensitive poly(N-isopropylacrylamide-co-methacrylic acid) hydrogel membrane. At fixed temperature (37 degrees C), lowering pH in one side of the cell induced hydrogel volume collapse and strongly attenuated glucose permeation across the membrane. Hysteresis was observed in the glucose permeability versus pH characteristic.
引用
收藏
页码:409 / 415
页数:7
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