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The genetics of health

被引：35
作者：
Nadeau, Joseph H. [1 ]
Topol, Eric J. [1 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Dept Genet, Cleveland, OH 44106 USA
来源：
NATURE GENETICS | 2006年 / 38卷 / 10期
关键词：
D O I：
10.1038/ng1006-1095
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent experience with several high-profile drugs demonstrates the great challenges in developing effective and safe therapeutics. A complementary approach to the popular paradigm of disease genetics is based on inherited factors that reduce the incidence and severity of disease among individuals who are genetically predisposed to disease. We propose testing specifically for modifier genes and protective alleles among at-risk individuals and studying the efficacy of therapeutics based on the genetics of health.
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页码：1095 / 1098
页数：4
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