The genetics of health

被引：35

作者：

Nadeau, Joseph H. ^{[1
]}

Topol, Eric J. ^{[1
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Genet, Cleveland, OH 44106 USA

来源：

NATURE GENETICS | 2006年 / 38卷 / 10期

关键词：

D O I：

10.1038/ng1006-1095

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent experience with several high-profile drugs demonstrates the great challenges in developing effective and safe therapeutics. A complementary approach to the popular paradigm of disease genetics is based on inherited factors that reduce the incidence and severity of disease among individuals who are genetically predisposed to disease. We propose testing specifically for modifier genes and protective alleles among at-risk individuals and studying the efficacy of therapeutics based on the genetics of health.

引用

页码：1095 / 1098

页数：4

共 53 条

[51] Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration
Zareparsi, S
Branham, KEH
Li, MY
Shah, S
Klein, RJ
Ott, J
Hoh, J
Abecasis, GR
Swaroop, A
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 77 (01) : 149 - 153
[52] Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice
Zheng, QY
Johnson, KR
[J]. HEARING RESEARCH, 2001, 154 (1-2) : 45 - 53
[53] Detection of a cystic fibrosis modifier locus for meconium ileus on human chromosome 19q13
Zielenski, J
Corey, M
Rozmahel, R
Markiewicz, D
Aznarez, I
Casals, T
Larriba, S
Mercier, B
Cutting, GR
Krebsova, A
Macek, M
Langfelder-Schwind, E
Marshall, BC
DeCelie-Germana, J
Claustres, M
Palacio, A
Bal, J
Nowakowska, A
Ferec, C
Estivill, X
Durie, P
Tsui, LC
[J]. NATURE GENETICS, 1999, 22 (02) : 128 - 129

← 1 2 3 4 5 6 →