Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion

被引：69

作者：

Kunimasa, Kazuhiro ^{[2
]}

Kuranuki, Sachi ^{[1
]}

Matsuura, Nobuyasu ^{[3
]}

Iwasaki, Nozomi ^{[1
]}

Ikeda, Megumi ^{[1
]}

Ito, Akira ^{[4
]}

Sashida, Yutaka ^{[4
]}

Mimaki, Yoshihiro ^{[4
]}

Yano, Masamichi ^{[5
]}

Sato, Mayumi ^{[6
]}

Igarashi, Yasuhiro ^{[7
]}

Oikawa, Tsutomu ^{[1
]}

机构：

[1] Kanagawa Univ Human Serv, Sch Nutr & Dietet, Kanagawa 2388522, Japan

[2] Univ Shizuoka, Lab Cell & Mol Biol Aging, Suruga ku, Shizuoka 4228526, Japan

[3] Okayama Univ Sci, Fac Sci, Okayama 7000005, Japan

[4] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

[5] Biooriented Technol Res Adv Inst, Minato Ku, Tokyo 1050001, Japan

[6] Tokyo Metropolitan Inst Med Sci, Bunkyo Ku, Tokyo 1138613, Japan

[7] Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 07期

关键词：

Nobiletin; Polymethoxyflavonoid; Adiponectin; Lifestyle-related diseases; ST-13; preadipocyte; METABOLIC SYNDROME; DIFFERENTIATION; ADIPOCYTES; EXPRESSION; PROTEIN; CELLS;

D O I：

10.1016/j.bmcl.2009.02.002

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Adiponectin, an adipocyte-derived protein with insulin-sensitizing, anti-diabetic and anti-atherogenic activities, is known to be induced during adipocyte differentiation. Nobiletin, a citrus polymethoxyflavonoid, was found to induce the differentiation of ST-13 preadipocytes into mature adipocytes and enhance the production of adiponectin protein at a concentration of 10 mu M. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2062 / 2064

页数：3

共 16 条

[1]

Anandamide induced PPARγ transcriptional activation and 3T3-L1 preadipocyte differentiation [J].