NAP mechanisms of neuroprotection

被引：53

作者：

Gozes, I ^{[1
]}

Steingart, RA

Spier, AD

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Dept Clin Biochem, IL-69978 Tel Aviv, Israel

[2] Allon Therapeut Inc, La Jolla, CA USA

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2004年 / 24卷 / 01期

关键词：

peptides; neuroprotection;

D O I：

10.1385/JMN:24:1:067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An 8-amino-acid peptide, NAPVSIPQ (NAP), was identified as the smallest active element of activity-dependent neuroprotective protein that exhibits potent neuroprotective action. Potential signal transduction pathways include cGMP production and interference with inflammatory mechanisms, tumor necrosis factor-alpha, and MAC1-related changes. Because of its intrinsic structure, NAP might interact with extracellular proteins and also transverse membranes. NAP-associated protection against oxidative stress, glucose deprivation, and apoptotic mechanisms suggests interference with fundamental processes. This paper identifies p53, a key regulator of cellular apoptosis, as an intracellular target for NAP's activity.

引用

页码：67 / 72

页数：6

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