Rivastigmine reverses cognitive deficit and acetylcholinesterase activity induced by ketamine in an animal model of schizophrenia

被引：19

作者：

Zugno, Alexandra I. ^{[1
,2
,3
]}

Juliao, Ricardo Filipe ^{[1
,2
]}

Budni, Josiane ^{[1
,2
]}

Volpato, Ana Maria ^{[1
,2
]}

Fraga, Daiane B. ^{[1
,2
]}

Pacheco, Felipe D. ^{[1
,2
]}

Deroza, Pedro F. ^{[1
,2
]}

Luca, Renata D. ^{[1
,2
]}

de Oliveira, Mariana B. ^{[1
,2
]}

Heylmann, Alexandra S. ^{[1
,2
]}

Quevedo, Joao ^{[1
,2
]}

机构：

[1] Univ Extremo Sul Catarinense, Lab Neurociencias, Inst Nacl Ciencia & Tecnol Translac Med INCT TM, BR-88806000 Criciuma, SC, Brazil

[2] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, Nucleo Excelencia Neurociencias Aplicadas Santa C, BR-88806000 Criciuma, SC, Brazil

[3] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, Lab Neurociencias, BR-88806000 Criciuma, SC, Brazil

来源：

METABOLIC BRAIN DISEASE | 2013年 / 28卷 / 03期

关键词：

Schizophrenia; Ketamine; Memory; Acetylcholinesterase; Locomotor activity; Rivastigmine; NMDA RECEPTOR HYPOFUNCTION; ALPHA-7 NICOTINIC RECEPTOR; CHOLINESTERASE-INHIBITORS; SUSTAINED ATTENTION; PREFRONTAL CORTEX; KINASE-ACTIVITY; RAT BEHAVIOR; SMOKING; PREVALENCE; ACETYLTRANSFERASE;

D O I：

10.1007/s11011-013-9417-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Schizophrenia is one of the most disabling mental disorders that affects up to 1 % of the population worldwide. Although the causes of this disorder remain unknown, it has been extensively characterized by a broad range of emotional, ideational and cognitive impairments. Studies indicate that schizophrenia affects neurotransmitters such as dopamine, glutamate and acetylcholine. Recent studies suggest that rivastigmine (an acetylcholinesterase inhibitor) is important to improve the cognitive symptoms of schizophrenia. Therefore, the present study evaluated the protective effect of rivastigmine against the ketamine-induced behavioral (hyperlocomotion and cognitive deficit) and biochemical (increase of acetylcholinesterase activity) changes which characterize an animal model of schizophrenia in rats. Our results indicated that rivastigmine was effective to improve the cognitive deficit in different task (immediate memory, long term memory and short term memory) induced by ketamine in rats. Moreover, we observed that rivastigmina reversed the increase of acetylcholinesterase activity induced by ketamine in the cerebral cortex, hippocampus and striatum. However, rivastigmine was not able to prevent the ketamine-induced hyperlocomotion. In conslusion, ours results indicate that cholinergic system might be an important therapeutic target in the physiopathology of schizophrenia, mainly in the cognition, but additional studies should be carried.

引用

页码：501 / 508

页数：8

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