Docetaxel: Overview of an active drug for breast cancer

被引：24

作者：

Crown, J ^{[1
]}

机构：

[1] St Vincents Hosp, Dublin 4, Ireland

来源：

ONCOLOGIST | 2001年 / 6卷

关键词：

adjuvant; breast cancer; docetaxel; paclitaxel; differentiation;

D O I：

10.1634/theoncologist.6-suppl_3-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Docetaxel and paclitaxel differ in their precise molecular targets and pharmacokinetics. Docetaxel is more avidly taken up by tumor cell lines than paclitaxel, and its efflux is slower. Comparative cytotoxicity data suggest greater potency. These factors may help explain the clinical differences that have been observed between the taxanes in patients with breast cancer.

引用

页码：1 / 4

页数：4

共 24 条

[1] BELLOT R, 1998, P AN M AM SOC CLIN, V17, pA221
[2] PHARMACOKINETICS OF TAXOL AND DOXORUBICIN ADMINISTERED ALONE AND IN COMBINATION BY CONTINUOUS 72-HOUR INFUSION
BERG, SL
COWAN, KH
BALIS, FM
FISHERMAN, JS
DENICOFF, AM
HILLIG, M
POPLACK, DG
OSHAUGHNESSY, JA
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (02) : 143 - 145
[3] BISSERY MC, 1991, CANCER RES, V51, P4845
[4] DOCETAXEL (TAXOTERE(R)) - A REVIEW OF PRECLINICAL AND CLINICAL-EXPERIENCE .1. PRECLINICAL EXPERIENCE
BISSERY, MC
NOHYNEK, G
SANDERINK, GJ
LAVELLE, F
[J]. ANTI-CANCER DRUGS, 1995, 6 (03) : 339 - 355
[5] Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer
Bruno, R
Hille, D
Riva, A
Vivier, N
Huinnink, WWTB
van Oosterom, AT
Kaye, SB
Verweij, J
Fossella, FV
Valero, V
Rigas, JR
Seidman, AD
Chevallier, B
Fumoleau, P
Burris, HA
Ravclin, PM
Sheiner, LB
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (01) : 187 - 196
[6] Prospective randomized trial of docetaxel versus doxorubicin in patients with metastatic breast cancer
Chan, S
Friedrichs, K
Noel, D
Pintér, T
Van Belle, S
Vorobiof, D
Duarte, R
Gil, MG
Bodrogi, I
Murray, E
Yelle, L
von Minckwitz, G
Korec, S
Simmonds, P
Buzzi, F
Mancha, RG
Richardson, G
Walpole, E
Ronzoni, M
Murawsky, M
Alakl, M
Riva, A
Crown, J
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (08) : 2341 - 2354
[7] Crown J, 1999, SEMIN ONCOL, V26, P5
[8] ASSEMBLY OF PURIFIED GDP TUBULIN INTO MICROTUBULES INDUCED BY TAXOL AND TAXOTERE - REVERSIBILITY, LIGAND STOICHIOMETRY, AND COMPETITION
DIAZ, JF
ANDREU, JM
[J]. BIOCHEMISTRY, 1993, 32 (11) : 2747 - 2755
[9] Gehl J, 1996, ANN ONCOL, V7, P687
[10] Human pharmacokinetic characterization and in vitro study of the interaction between doxorubicin and paclitaxel in patients with breast cancer
Gianni, L
Vigano, L
Locatelli, A
Capri, G
Giani, A
Tarenzi, E
Bonadonna, G
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (05) : 1906 - 1915

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