Self-Optimizing Reactor Systems: Algorithms, On-line Analytics, Setups, and Strategies for Accelerating Continuous Flow Process Optimization

被引:48
作者
Fabry, David C. [1 ]
Sugiono, Erli [1 ]
Rueping, Magnus [1 ]
机构
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
关键词
asymmetric reduction; cross-coupling; hydrogenation; microreactor; Suzuki reaction; HECK REACTION; ARTIFICIAL PHOTOSYNTHESIS; MICROREACTOR SYSTEM; COUPLING REACTIONS; WATER OXIDATION; PALLADIUM; CATALYSTS; MICROWAVE; ARYL; HYDROGENATION;
D O I
10.1002/ijch.201300080
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This review provides an overview of recent developments in the area of continuous flow process optimization by employing self-optimizing reactor systems. Although only few reactor concepts have been realized to date, impressive progress has been made, which now allows fully automated reaction optimization without the need of human interactions.
引用
收藏
页码:341 / 350
页数:10
相关论文
共 94 条
[81]   Continuous asymmetric hydrogenation in supercritical carbon dioxide using an immobilised homogeneous catalyst [J].
Stephenson, Phil ;
Kondor, Betti ;
Licence, Peter ;
Scovell, Katherine ;
Ross, Stephen K. ;
Poliakoff, Martyn .
ADVANCED SYNTHESIS & CATALYSIS, 2006, 348 (12-13) :1605-1610
[82]   A nano-modified Si/TiO2 composite electrode for efficient solar water splitting [J].
Takabayashi, S ;
Nakamura, R ;
Nakato, Y .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2004, 166 (1-3) :107-113
[83]   High-throughput methods for the development of new catalytic asymmetric reactions [J].
Traverse, JF ;
Snapper, ML .
DRUG DISCOVERY TODAY, 2002, 7 (19) :1002-1012
[84]   Application of excitation-emission fluorescence matrices and UV/Vis absorption to monitoring the photocatalytic degradation of commercial humic acid [J].
Valencia, Sergio ;
Marin, Juan M. ;
Restrepo, Gloria ;
Frimmel, Fritz H. .
SCIENCE OF THE TOTAL ENVIRONMENT, 2013, 442 :207-214
[85]   High-throughput screening for biocatalysts [J].
Wahler, D ;
Reymond, JL .
CURRENT OPINION IN BIOTECHNOLOGY, 2001, 12 (06) :535-544
[86]   Continuous flow multi-step organic synthesis [J].
Webb, Damien ;
Jamison, Timothy F. .
CHEMICAL SCIENCE, 2010, 1 (06) :675-680
[87]   Flow Chemistry - A Key Enabling Technology for (Multistep) Organic Synthesis [J].
Wegner, Jens ;
Ceylan, Sascha ;
Kirschning, Andreas .
ADVANCED SYNTHESIS & CATALYSIS, 2012, 354 (01) :17-57
[88]   Ultrahigh-efficiency photocatalysts based on mesoporous Pt-WO3 nanohybrids [J].
Wen, Zhenhai ;
Wu, Wei ;
Liu, Zhuang ;
Zhang, Hao ;
Li, Jinghong ;
Chen, Junhong .
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2013, 15 (18) :6773-6778
[89]   Continuous flow reactors, a tool for the modern synthetic chemist [J].
Wiles, Charlotte ;
Watts, Paul .
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2008, 2008 (10) :1655-1671
[90]   Continuous flow reactors: a perspective [J].
Wiles, Charlotte ;
Watts, Paul .
GREEN CHEMISTRY, 2012, 14 (01) :38-54