Approaching the in vitro clinical trial: engineering organs on chips

被引：91

作者：

Capulli, A. K. ^{[1
]}

Tian, K. ^{[1
]}

Mehandru, N. ^{[1
]}

Bukhta, A. ^{[1
]}

Choudhury, S. F. ^{[1
]}

Suchyta, M. ^{[1
]}

Parker, K. K. ^{[1
]}

机构：

[1] Harvard Univ, Sch Engn & Appl Sci, Wyss Inst Biol Inspired Engn, Dis Biophys Grp, Cambridge, MA 02138 USA

来源：

LAB ON A CHIP | 2014年 / 14卷 / 17期

基金：

美国国家卫生研究院;

关键词：

DRUG DEVELOPMENT; SYSTEMS BIOLOGY; CELLS; MICROFLUIDICS; ABSORPTION; ENCAINIDE; MATRIX;

D O I：

10.1039/c4lc00276h

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

In vitro cell culture and animal models are the most heavily relied upon tools of the pharmaceutical industry. When these tools fail, the results are costly and have at times, proven deadly. One promising new tool to enhance preclinical development of drugs is Organs on Chips (OOCs), proposed as a clinically and physiologically relevant means of modeling health and disease. Bringing the patient from bedside to bench in this form requires that the design, build, and test of OOCs be founded in clinical observations and methods. By creating OOCs as models of the patient, the industry may be better positioned to evaluate medicinal therapeutics

引用

收藏

页码：3181 / 3186

页数：6

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