Annexin 1 and the biology of the neutrophil

被引：108

作者：

Perretti, M ^{[1
]}

Flower, RJ ^{[1
]}

机构：

[1] Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2004年 / 76卷 / 01期

关键词：

glucocortoids; anti-inflammation; lipocortin; adhesion; trafficking; endothelium;

D O I：

10.1189/jlb.1103552

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This overview will focus on one aspect of neutrophil biology, which is the selective activation of the annexin 1 system in relation to the process of cell extravasation. Besides the current view about the biochemistry of annexin 1 and annexin 1 receptor(s) up-regulation within the microenvironment of the adherent neutrophils, we will also comment on the final result achieved by activation of the system, which is inhibition of neutrophil recruitment. In view of the historical link between annexin 1 and glucocorticoids, the potential for the annexin 1 system in mediating at least sonic of the anti-inflammatory actions of these powerful drugs is also discussed.

引用

页码：25 / 29

页数：5

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