Mitochondrial form and function

被引：1576

作者：

Friedman, Jonathan R. ^{[1
]}

Nunnari, Jodi ^{[1
]}

机构：

[1] Univ Calif Davis, Coll Biol Sci, Dept Mol & Cellular Biol, Davis, CA 95616 USA

来源：

NATURE | 2014年 / 505卷 / 7483期

关键词：

ENDOPLASMIC-RETICULUM; TRANSCRIPTION FACTOR; SACCHAROMYCES-CEREVISIAE; MAMMALIAN-CELLS; INNER MEMBRANE; NUCLEOID STRUCTURE; CALCIUM UNIPORTER; CRYSTAL-STRUCTURE; MTDNA STABILITY; DNA REPLICATION;

D O I：

10.1038/nature12985

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells. Owing to their ability to produce ATP through respiration, they became a driving force in evolution. As an essential step in the process of eukaryotic evolution, the size of the mitochondrial chromosome was drastically reduced, and the behaviour of mitochondria within eukaryotic cells radically changed. Recent advances have revealed how the organelle's behaviour has evolved to allow the accurate transmission of its genome and to become responsive to the needs of the cell and its own dysfunction.

引用

页码：335 / 343

页数：9

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