Site-2 proteases in prokaryotes: regulated intramembrane proteolysis expands to microbial pathogenesis

被引：45

作者：

Makinoshima, Hideki

Glickman, Michael S.

机构：

[1] Mem Sloan Kettering Canc Ctr, Div Infect Dis, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Program Immunol, New York, NY 10021 USA

来源：

MICROBES AND INFECTION | 2006年 / 8卷 / 07期

关键词：

regulated intramembrane proteolysis; site-2; protease; membrane zinc metalloprotease; lipid regulation; Mycobacterium tuberculosis; microbial pathogenesis; cell membrane;

D O I：

10.1016/j.micinf.2006.02.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulated intramembrane proteolysis (RIP) is a widely distributed mechanism of signal transduction in which membrane-bound proteases cleave transmembrane domains of substrate proteins. The site-2 protease (S2P) class of RIP metalloproteases is present in most bacterial genomes but is generally of unknown function except for the well -characterized proteases RseP and SpoIVFB. In this review we will discuss the biochemical functions and physiologic roles of S2P proteases in bacteria and highlight recent data implicating S2P family members in host-pathogen interactions. (c) 2006 Elsevier SAS. All rights reserved.

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页码：1882 / 1888

页数：7

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